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Aptiom® (eslicarbazepine acetate) Savings Program

When a person has partial-onset seizures, we understand that the cost of antiseizure medication is the last thing they want to worry about. The APTIOM Savings Program provides options for your patients.*

Order the Savings Card* and High-Deductible Discount Card to help patients save on their APTIOM prescriptions (packs of 25)

Aptiom Order Voucher

Aptiom Order Voucher

Not an actual card.

Aptiom Order Voucher

Aptiom Order Voucher

Not an actual card.

  • Co-pays could be as little as $10, with savings up to $75 on APTIOM prescription fills*
  • Patients with high-deductible commercial insurance plans can pay as little as $35 out-of-pocket for APTIOM
  • Enrolled patients also receive co-pay assistance, product information, personalized support, and additional resource information

*For qualifying patients only. Restrictions apply. Co-pay amounts may vary. Maximum reduction of up to $75 per prescription fill. May not be used with any other offer for APTIOM. See program rules and eligibility requirements below.
†Restrictions apply. For commercially insured patients, this High-Deductible Discount Card covers out-of-pocket expenses greater than $35 per prescription, with a maximum benefit of up to $500 each for three 30-day prescriptions. May not be used with any other offer for APTIOM. See program rules and eligibility requirements below.

Order vouchers to offer patients a no-cost 14-day supply of APTIOM (packs of 25)

Aptiom Order Voucher

Aptiom Order Voucher

Not an actual card.

‡For qualifying patients only. Restrictions apply. Limit 1 voucher per patient per lifetime. See program rules and eligibility requirements below.

To place a request:

Select the material type, quantity, and shipping information below. Then click Request Savings Materials.

You must be logged in to request savings materials.

Please Log in or Register

 

Savings Card Terms and Conditions:

By using this card, you acknowledge that you currently meet the following eligibility requirements:

  • You must be 18 years of age or older to accept this offer.  This offer is valid only for eligible patients and legal guardians of eligible patients. Patients must have a valid prescription for APTIOM within APTIOM’s approved indication
  • Offer not valid if prescription is paid in part or full by any state or federally funded health care program, including but not limited to Medicare, Medicaid, VA, DOD or TRICARE, or where prohibited by law
  • This card is valid for up to $75 off each prescription fill for up to a 30-day supply.  The card is further limited to twelve (12) qualifying prescription fills per calendar year
  • Offer is limited to one per person and may not be used with any other offer
  • This program is not health insurance. The amount of the benefit cannot exceed the patient’s out-of-pocket expenses. Acceptance of this offer must be consistent with the terms of any drug benefit provided by a health insurer, health plan, or other third-party payer. If requested or required by any such payer, the patient must report the use of this card. The patient must deduct the value of the savings received under this program from any reimbursement request submitted to the patient’s insurance plan, either directly or on the patient’s behalf
  • For California and Massachusetts residents, benefits pursuant to this card will terminate automatically upon the introduction of a therapeutically equivalent product
  • Offer valid only in the United States and Puerto Rico. Void where prohibited by law, taxed or restricted
  • Sunovion reserves the right to rescind, revoke or amend this offer at any time without notice. This offer is not transferable and may not be sold, purchased or traded, or offered for sale, purchase or trade

High-Deductible Discount Card Program Terms and Conditions:

  • This offer is valid only for eligible patients 18 years of age or older, or legal guardians of patients between 4 and 17 years of age with a valid prescription for APTIOM
  • Offer limited to one per person and may not be used with any other offer for APTIOM
  • High-deductible commercial insurance required
  • Cash-paying patients are not eligible
  • Patients are not eligible if prescriptions are paid in part or full by any state or federally funded health care programs, including but not limited to Medicare, Medicaid, VA, DOD, TRICARE, or where prohibited by law
  • Activation is required to use this card
  • This card is valid for up to $500 off each of up to 3 qualifying prescriptions for up to a 30-day supply, and may not be used with any other offer. Patient is responsible for the first $35 of their co-pay and any additional out-of-pocket costs above $500
  • For patients using this card for a 90-day prescription fill, this card may only be used one time
  • This program is not health insurance
  • Offer valid only in the United States and Puerto Rico. Void where prohibited by law, taxed, or restricted
  • Sunovion reserves the right to rescind, revoke, or amend this offer at any time without notice. This offer is not transferable and may not be sold, purchased, or traded, or offered for sale, purchase, or trade
  • Offer expires 12/31/2018

14-Day Trial Voucher Terms and Conditions:

  • You must be 18 years of age or older to accept this offer. This offer is valid only for eligible patients and legal guardians of eligible patients. Patients must have a valid prescription for APTIOM within APTIOM's approved indication
  • This voucher is valid for a 14-day supply of APTIOM
  • Limit 1 voucher per patient per lifetime
  • No purchase necessary. Refills are not required
  • This voucher is not transferable. No substitutions are permitted. This offer cannot be combined with any other free trial, coupon, discount, prescription savings card, or other offer
  • This voucher is not health insurance. Claim shall not be submitted to any public or private third-party payer or any federal or state health care program for reimbursement
  • Offer valid only in the United States and Puerto Rico. Void where prohibited by law, taxed or restricted
  • It is illegal to sell, purchase, trade, or counterfeit, or offer to sell, purchase, trade, or counterfeit this voucher. Void if reproduced
  • Sunovion reserves the right to rescind, revoke or amend this offer at any time without notice

McKesson Corporation retains the right to review all records and documentation relating to the filling/dispensing of the product.

Important Safety Information & Indications

Contraindications: APTIOM is contraindicated in patients with a hypersensitivity to eslicarbazepine acetate or oxcarbazepine.

Suicidal Behavior and Ideation: Antiepileptic drugs (AEDs), including APTIOM, increase the risk of suicidal thoughts or behavior. Anyone considering prescribing APTIOM or any other AED must balance this risk with the risk of untreated illness. Epilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. Patients and caregivers should also be advised to be alert to these behavioral changes and to immediately report them to the health care provider.

Serious Dermatologic Reactions, including Stevens‐Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN), have been reported in association with APTIOM use. Serious and sometimes fatal dermatologic reactions, including TEN and SJS, have also been reported in patients using oxcarbazepine or carbamazepine, which are chemically related to APTIOM. Should a patient develop a dermatologic reaction while using APTIOM, discontinue APTIOM use unless it is clearly not drug related.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), also known as Multiorgan Hypersensitivity, has been reported in patients taking APTIOM. DRESS typically, although not exclusively, presents with fever, rash, and/or lymphadenopathy, in association with other organ system involvement. If this reaction is suspected, treatment with APTIOM should be discontinued.

Anaphylactic Reactions and Angioedema: Rare cases of anaphylaxis and angioedema have been reported in patients taking APTIOM. Anaphylaxis and angioedema associated with laryngeal edema can be fatal. If a patient develops any of these reactions, the drug should be discontinued. Patients with a prior anaphylactic‐type reaction after treatment with either oxcarbazepine or APTIOM should not be treated with APTIOM.

Hyponatremia: Clinically significant hyponatremia (sodium <125 mEq/L) and syndrome of inappropriate antidiuretic hormone secretion (SIADH) can develop in patients taking APTIOM. Measurement of serum sodium and chloride levels should be considered during maintenance treatment with APTIOM, particularly if the patient is receiving other medications known to decrease serum sodium levels. Depending on the severity of hyponatremia, the dose of APTIOM may need to be reduced or discontinued.

Neurological Adverse Reactions: APTIOM causes dose‐dependent increases in the following reactions (dizziness, disturbance in gait and coordination, somnolence, fatigue, and visual changes). There was an increased risk of dizziness, disturbance in gait and coordination, and visual changes during the titration period (compared to maintenance treatment), and there may be an increased risk of these adverse reactions in patients 60 years of age and older compared to younger adults. APTIOM causes dose-dependent increases in cognitive dysfunction-related events in adults (memory impairment, disturbance in attention, amnesia, confusional state, aphasia, speech disorder, slowness of thought, disorientation, and psychomotor retardation). The incidences of dizziness and diplopia were greater with concomitant use of APTIOM and carbamazepine compared to the use of APTIOM without carbamazepine.

Prescribers should advise patients against engaging in hazardous activities requiring mental alertness, such as operating motor vehicles or dangerous machinery, until the effect of APTIOM is known.

Withdrawal of AEDs: As with all AEDs, APTIOM should be withdrawn gradually because of the risk of increased seizure frequency and status epilepticus, but if withdrawal is needed because of a serious adverse event, rapid discontinuation can be considered.

Drug Induced Liver Injury: Hepatic effects, ranging from mild to moderate elevations in transaminases (>3 times the upper limit of normal) to rare cases with concomitant elevations of total bilirubin (>2 times the upper limit of normal) have been reported with APTIOM use. Baseline evaluations of liver laboratory tests are recommended. APTIOM should be discontinued in patients with jaundice or other evidence of significant liver injury.

Abnormal Thyroid Function Tests: Dose‐dependent decreases in serum T3 and T4 (free and total) values have been observed in patients taking APTIOM. These changes were not associated with other abnormal thyroid function tests suggesting hypothyroidism. Abnormal thyroid function tests should be clinically evaluated.

Hematologic Adverse Reactions: Rare cases of pancytopenia, agranulocytosis, and leukopenia have been reported during postmarketing use in patients treated with APTIOM. Discontinuation of APTIOM should be considered in patients who develop pancytopenia, agranulocytosis, or leukopenia.

Most Common Adverse Reactions: The most common adverse reactions in adult patients receiving APTIOM (≥4% and ≥2% greater than placebo) were dizziness, somnolence, nausea, headache, diplopia, vomiting, fatigue, vertigo, ataxia, blurred vision, and tremor. Adverse reactions in pediatric patients are similar to those seen in adult patients.

Safety and Efficacy in Patients <4 Years of Age: Safety and effectiveness in patients below 4 years of age have not been established.

Dosing Considerations
Some adverse reactions occur more frequently when patients take APTIOM adjunctively with carbamazepine. When APTIOM and carbamazepine are taken concomitantly, the dose of APTIOM or carbamazepine may need to be adjusted based on efficacy and tolerability. APTIOM should not be taken as an adjunctive therapy with oxcarbazepine. For patients taking other enzyme‐inducing AEDs (i.e., phenobarbital, phenytoin, and primidone), higher doses of APTIOM may be needed.

A dose reduction is recommended in patients with moderate and severe renal impairment (i.e., creatinine clearance <50 mL/min).

Dose adjustments are not required in patients with mild to moderate hepatic impairment. Use of APTIOM in patients with severe hepatic impairment has not been studied, and use in these patients is not recommended.

Concomitant use of APTIOM and oral contraceptives containing ethinylestradiol and levonorgestrel is associated with lower plasma levels of these hormones. Patients should use additional or alternative non‐hormonal birth control during APTIOM treatment and after discontinuation of APTIOM for one menstrual cycle, or until otherwise instructed.


Indications and Usage
Aptiom® (eslicarbazepine acetate) is indicated for the treatment of partial‐onset seizures in patients 4 years of age and older.

Before prescribing APTIOM, please read the Full Prescribing Information.