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Patient Profiles

Help your patients with bipolar depression experience more of life's everyday moments.

*Not an actual patient. The Licensed Material is being used for illustrative purposes only. Any person depicted in the Licensed Material, if any, is a model.


Learn more about the types of patients in your practice that may be appropriate for treatment with LATUDA

Click on the patient's photos below to learn more about who they are and how they are currently dealing with their bipolar depression.

Overview
maya-profile

  • Female, age 33
  • Self-employed; longtime ceramics hobby
  • Married with 1 child
History
maya-profile

History

  • Patient reports mood and energy problems since early adulthood, but for years attributed them to having "an artistic temperament"
  • Recently diagnosed with bipolar I disorder (9 months ago)
  • Comorbid conditions: insomnia, history of substance abuse
  • Previous treatment: various antidepressants
  • Current medications: SSRI and anxiolytic
Presentation
maya-profile

Presentation

  • Chief complaints: lack of interest and energy in daily activities; family and work relationships have become strained
  • Feels bad about not spending more time with her daughter and husband
  • Husband reports that patient’s mood shifts have become shorter and more frequent
Overview
Patient_Profile_Zoe

  • Female, age 15
  • High school student
History
Patient_Profile_Zoe

History

  • Patient has exhibited emotional and academic difficulties present since around age 4
  • Diagnosed with major depressive disorder at age 13
  • Parents report she was an anxious and clingy child, who threw intense, prolonged tantrums at home and school; “moodiness” persisted into preteen and teen years with an increasing pattern of mood lability
  • Family history of bipolar disorder (maternal grandmother; first cousin)
  • Patient has strong family support, though peer relationships are limited, with few close friends
  • Current treatment: SSRI
Presentation
Patient_Profile_Zoe

Presentation

  • Patient presents with progressive depressive symptoms for the past 4 months
  • Chief complaints include difficulty sleeping, decreased energy, and irritable mood; patient also reports feelings of worthlessness and hopelessness
  • Recently diagnosed with bipolar l disorder, most recent episode depressed 
Overview
Patient_Profile_Gabe

  • Male, age 13
  • Middle school student
History
Patient_Profile_Gabe

History

  • Mother reports that patient was a colicky baby, hard to soothe, and did not readily settle into regular sleep and eating patterns; also described as a “hyper” and “hard to discipline” child 
  • Diagnosed with attention‐deficit/hyperactivity disorder at age 7 
  • Starting around age 10, moods have been marked by ongoing lability between impulsive energy needing constant redirection and irritable apathy 
  • Possible family history of mood disorder and substance use disorder (uncle took lithium; estranged from family) 
  • Taking medication for ADHD
Presentation
Patient_Profile_Gabe

Presentation

  • Patient presents for psychiatric evaluation due to worsening difficulties at home and at school over the past year
  • He reports persistent fatigue, irritability, and anger; patient admits to engaging in frequent fights with family, peers, and teachers
  • Frequently avoids or refuses to go to school; mother complains that it has become “excruciating” to try and get him up and out of bed
  • Diagnosed with bipolar l disorder, most recent episode depressed, following recent clinical evaluation  (1 month ago)

IMPORTANT SAFETY INFORMATION AND INDICATIONS FOR LATUDA

INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS; and SUICIDAL THOUGHTS AND BEHAVIORS

Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. LATUDA is not approved for the treatment of patients with dementia-related psychosis.

Suicidal Thoughts and Behaviors
Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adults in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors.

 

CONTRAINDICATIONS: LATUDA is contraindicated in the following:

Cerebrovascular Adverse Reactions, Including Stroke: In clinical trials, elderly subjects with dementia randomized to risperidone, aripiprazole, and olanzapine had a higher incidence of stroke and transient ischemic attack, including fatal stroke. LATUDA is not approved for the treatment of patients with dementia-related psychosis.

Neuroleptic Malignant Syndrome (NMS): NMS is a potentially fatal symptom complex reported with administration of antipsychotic drugs. Clinical signs of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability. Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure. Manage NMS with immediate discontinuation of antipsychotic drugs, including LATUDA, intensive symptomatic treatment and monitoring.

Tardive Dyskinesia (TD): The risk of developing TD (a syndrome of abnormal involuntary movements) and the potential for it to become irreversible are believed to increase as the duration of treatment and total cumulative dose of antipsychotic increase. The syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses or may even arise after discontinuation of treatment. The syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn.

Metabolic Changes Atypical antipsychotic drugs have caused metabolic changes including:

Hyperglycemia and Diabetes Mellitus: Hyperglycemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients treated with atypical antipsychotics. Patients with diabetes should be regularly monitored for worsening of glucose control; those with risk factors for diabetes should undergo fasting blood glucose testing at the beginning of and periodically during treatment. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia, including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia should undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of anti-diabetic treatment despite discontinuation of the suspect drug.

Dyslipidemia: Undesirable alterations in lipids have been observed in patients treated with atypical antipsychotics.

Weight Gain: Weight gain has been observed with atypical antipsychotic use. Clinical monitoring of weight is recommended.

Hyperprolactinemia: As with other drugs that antagonize dopamine D2 receptors, LATUDA elevates prolactin levels. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds.

Leukopenia, Neutropenia, and Agranulocytosis: Leukopenia/neutropenia has been reported with antipsychotics. Agranulocytosis (including fatal cases) has been reported with other agents in the class. Monitor complete blood count in patients with a pre-existing low white blood cell count (WBC)/absolute neutrophil count (ANC) or history of drug-induced leukopenia/neutropenia. Discontinue LATUDA at the first sign of a decline in WBC in the absence of other causative factors.

Orthostatic Hypotension and Syncope: Atypical antipsychotics cause orthostatic hypotension and syncope. Generally, the risk is greatest at the beginning of treatment and when increasing the dose. Monitor patients vulnerable to hypotension and those with cardiovascular and cerebrovascular disease.

Falls: Antipsychotics may cause somnolence, postural hypotension, or motor and sensory instability, which may lead to falls, causing fractures or other injuries. For patients with disease, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating treatment and recurrently during therapy.

Seizures: LATUDA should be used cautiously in patients with a history of seizures or with conditions that lower seizure threshold.

Potential for Cognitive and Motor Impairment: Patients should be cautioned about operating hazardous machinery, including motor vehicles, until they are reasonably certain that therapy with LATUDA does not affect them adversely.

Body Temperature Regulation: Use LATUDA with caution in patients who may experience conditions that increase body temperature (e.g., exercising strenuously, exposure to extreme heat, concomitant medication with anticholinergic activity, or being subject to dehydration).

Dysphagia: Antipsychotics, including LATUDA, have been associated with esophageal dysmotility and aspiration, and should be used with caution in patients at risk for aspiration pneumonia.

Most Commonly Observed Adverse Reactions: Commonly observed adverse reactions (≥5% incidence and at least twice the rate of placebo) for LATUDA:

To report SUSPECTED ADVERSE REACTIONS, contact Sunovion Pharmaceuticals Inc. at 877-737-7226 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

Indications

LATUDA is indicated for:

Before prescribing LATUDA, please read the full Prescribing Information, including Boxed Warnings.